The subject of this book is the epistemology of Willard Van Orman Quine who holds that the problems of knowledge are accessible to the methodology of the natural science. Based on the weaknesses of Quine\'s theory and its interpretations, Milos Bogdanovic argues that epistemological inquiry can ultimately be approached from one of two mutually incompatible perspectives: the traditional, or Cartesian, and the Kantian. In light of this, the author discusses the possibility of establishing a synthesis of Quine\'s approach with Kant\'s view. Apart from preserving certain naturalistic elements, it is an interpretation that would ultimately satisfy most of the demands that Quine himself placed on epistemological inquiry.